![Maretzky Lab spelled out in periodic table symbols](/sites/maretzky.lab.uiowa.edu/files/2024-07/maretzky_lab_sign-cropped.png)
Welcome to the Maretzky Lab!
About 80% of older adults have one chronic disease condition, and 50% have at least two such as cancer, cardiovascular diseases, progressive dementia, or connective tissue disorders. Our laboratory is investigating novel signaling pathways in chronic diseases, with a specific focus on inflammation-associated diseases.
Research Interests Include:
Studying the physiological relevance of the iRhom2/TACE signaling axis in the induction of inflammatory processes and characterizing the role of iRhom2/TACE in tissue degeneration and regeneration.
- Innate immune system
- Inflammation
- Host-Pathogen Interaction
- iRhoms in disease and development
- A Disintegrin and metalloprotease activation and regulation
Our laboratory uses a wide range of experimental techniques including molecular biology, protein chemistry, immunocytochemistry, cell culture, live-cell imaging, animal modeling , and computational systems biology analyses.