The aim of this Special Issue of IJMS is to provide novel insights into the physiological and pathological functions of these membrane-anchored molecular scissors. To this end, we welcome experts in the field to contribute research articles and critical reviews on molecular mechanisms involved in the regulation of these fascinating enzymes.
Immunology and Immune-Based Disease Treatment Retreat
We are attending the 6th annual retreat of the Center for Immunology and Immune-Based Disease in Iowa City on August 17, 2017
Here we report that ADAM9-dependent shedding of EphB4 is not stimulated by three commonly employed activators of ADAM-dependent ectodomain shedding: phorbol esters, pervanadate or calcium ionophores.
pSIVA live cell imaging of HaCaT keratinocyte stimulated with ionomycin (IO). IO induces rapid PS exposure spreading over the entire cell surface and remains sustained over the time of observation.
Video from: Nat Commun. 2016 May 10;7:11523. doi: 10.1038/ncomms11523. [Watch]
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis
Video from: J Clin Invest. 2013 Feb;123(2):928-32. doi: 10.1172/JCI66168. Epub 2013 Jan 25. Read more...
Priya Issuree and Thorsten Maretzky found that iRhom2 regulates TACE on immune cells, whereas iRhom1 is responsible for helping TACE mature elsewhere in the body, such as in brain, heart, kidney, liver, lung and spleen cells.