Phosphatidylserine exposure is required for ADAM17 sheddase function

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pSIVA live cell imaging of HaCaT keratinocyte stimulated with ionomycin (IO). IO induces rapid PS exposure spreading over the entire cell surface and remains sustained over the time of observation 

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Video from: Nat Commun. 2016 May 10;7:11523. doi: 10.1038/ncomms11523.


iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

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Video from: J Clin Invest. 2013 Feb;123(2):928-32. doi: 10.1172/JCI66168. Epub 2013 Jan 25.


Researchers Identify New Target for Rheumatoid Arthritis Drugs

Priya Issuree and Thorsten Maretzky
Priya Issuree and Thorsten Maretzky found that iRhom2 regulates TACE on immune cells, whereas iRhom1 is responsible for helping TACE mature elsewhere in the body, such as in brain, heart, kidney, liver, lung and spleen cells.