Selected Publications
Skurski J, Penniman CM, Geesala R, Dixit G, Pulipati P, Bhardwaj G, Meyerholz DK, Issuree PD, O'Neill BT, Maretzky T. Loss of iRhom2 accelerates fat gain and insulin resistance in diet-induced obesity despite reduced adipose tissue inflammation. Metabolism. 2020 Mar 2;106:154194. doi: 10.1016/j.metabol.2020.154194.
Geesala R, Issuree PD, Maretzky T. Novel functions of inactive rhomboid proteins in immunity and disease. J Leukoc Biol. 2019 Oct;106(4):823-835. doi: 10.1002/JLB.3VMR0219-069R. Epub 2019 Aug 1. Review.
Geesala R, Schanz W, Biggs M, Dixit G, Skurski J, Gurung P, Meyerholz DK, Elliott D, Issuree PD, Maretzky T. Loss of RHBDF2 results in an early-onset spontaneous murine colitis. J Leukoc Biol. 2019 Apr;105(4):767-781. doi: 10.1002/JLB.4A0718-283RR. Epub 2019 Jan 29.
Schaal JB, Maretzky T, Tran DQ, Tran PA, Tongaonkar P, Blobel CP, Ouellette AJ, Selsted ME. Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme. J Biol Chem. 2018 Feb 23;293(8):2725-2734. doi: 10.1074/jbc.RA117.000793. Epub 2018 Jan 9.
Maretzky T, Swendeman S, Mogollon E, Weskamp G, Sahin U, Reiss K, Blobel CP. Characterization of the Catalytic Properties of the Membrane-anchored Metalloprotease ADAM9 in Cell-based assays. Biochem J. 2017 Apr 13;474(9):1467-1479. doi: 10.1042/BCJ20170075.
Li X, Maretzky T, Perez-Aguilar JM, Monette S, Weskamp G, Le Gall S, Beutler B, Weinstein H, Blobel CP. Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2/ADAM17-dependent proteolysis. J Cell Sci. 2017 Mar 1;130(5):868-878. doi: 10.1242/jcs.196436. Epub 2017 Jan 19.
Li X, Maretzky T, Weskamp G, Monette S, Qing X, Issuree PD, Crawford H, McIlwain DR, Mak TW, Salmon JE, Blobel CP. iRhoms1 and 2 are essential for ADAM17-dependent EGFR signaling during mouse development. Proc Natl Acad Sci U S A. 2015 May 12;112(19):6080-5. doi: 10.1073/pnas.1505649112. Epub 2015 Apr 27.
Maretzky T, McIlwain DR, Issuree PD, Li X, Malapeira J, Amin S, Lang PA, Mak TW, Blobel CB. iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11433-8. doi: 10.1073/pnas.1302553110. Epub 2013 Jun 25.
McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, Ohashi PS, Blobel CP, Mak TW. iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS. Science. 2012 Jan 13;335(6065):229-32
Maretzky T, Evers A, Zhou W, Swendeman SL, Wong PM, Rafii S, Reiss K, Blobel CP. Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17. Nat Commun. 2011 Mar; 2:229.
Lab Presentations
January 2018
Skurski J, Issuree PA, Blobel CP, Maretzky T. Induction and Regulation of LPS-induced inflammatory responses in murine Bone Marrow Derived Macrophages. Common Interview Weekend Poster Session, January 27, 2018 MERF Atrium, Iowa City (IA)
October 2017
Schanz S and Maretzky T. iRhom2/TACE-dependent TNFα and HB-EGF/EGFR signaling in obesity. Department of Internal Medicine Research Day October 10, 2017 MERF Atrium, Iowa City (IA)
Schanz S, Calcopietro C, Biggs, M, Maretzky T. The role of ADAM17-mediated shedding of leukocyte cell surface proteins in inflammation and gut homeostasis.
SLB 50th Anniversary Meeting October 5 to 7, 2017 at the Westin Bayshore in Vancouver, Canada
August 2017
Schanz S, Calcopietro C, Maretzky T. The role of ADAM17-mediated TNFa signaling in inflammatory diseases.
Center for Immunology Annual Retreat August 17, 2017 at the Sheraton Hotel, downtown, Iowa City (IA)